Translational Proteomics

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Translational Proteomics 2016-11-10T20:29:44+00:00

Research overview–efficient translation of MS-based biomarker discovery research into routine methods, integration of genomics, proteomics and metabolomics.

 

Taking markers from discovery to routine

Once biomarkers are discovered they must be verified and then validated in an environment that conforms to regulatory and QC requirements, if they are to be used in routine tests.  Articles of note ›

Translating ELISA’s to targeted MS methods

Although ELISA and other immunoassay methods have become the “gold standard” for clinical tests, they often suffer from a lack of specificity. Typically, this may be due to non-specific binding to the selected antibody. In addition, there is a lack of agreement across multiple ELISA platforms. Using a mass spectrometer as the detector can address many of these issues because the MS data will identify the bound analyte specifically at the sequence level. Articles of note ›

Designing verification studies for new markers

Verification of putative biomarkers requires the integration of statistical, quality control and sample collection protocols. Articles of note ›

Integration of genomics, proteomics and metabolomics

The “omics” revolution heralds new era for biomedicine. It promises to provide a more “holistic” view of the condition of an individual, resulting in more preventive, predictive and personalized medicine than available today. This comprehensive perspective addresses the identification, characterization and quantitation of the entire repertoire of genes, proteins and metabolites occurring in an individual. These articles review recent scientific advances and new technologies used to integrate genomics, metabolomics and proteomics information. Articles of note ›