Targeted Discovery

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Targeted Discovery 2016-11-10T20:23:38+00:00

Research overview—MS-based marker panels, phospho-signaling, and post-translational modifications (PTMs) for biological pathway elucidation

 

Marker panels for biological pathways

Recent research portends the role of MS-based proteomics as useful tool for understanding complex biological pathways, a field known as systems biology. These papers explore the ability of MS to identify and quantify thousands of proteins in complex samples. Articles of note ›

Targeted MS of phospho-signaling pathways

Cellular communication and information processing is performed by complex, dynamic, and context specific signaling networks. This signaling is largely controlled by protein phosphorylation. Abnormal phosphorylation is one of the underlying mechanisms for the development of cancer and metabolic disorders. Advancements in the sensitivity of MS methods and the development of antibodies that detect phosphorylations are beginning to allow study of phos-signaling pathways. Articles of note ›

Targeted MS measurement of proteins in epigenetics

Lack of cell differentiation is one of the leading causes of cancers and epigenetic regulation is being explored as an underlying molecular mechanism controlling cell proliferation or differentiation. MS-based proteomics is already an integrated and indispensable tool for chromatin biology and the characterization of the post-translational modifications (PTMs) of histones providing insights into the mechanisms and dynamics of epigenetic processes. Articles of note ›