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So far Jentech has created 143 blog entries.

Novel Huntington’s Disease Biomarkers

Huntington’s disease (HD) is a genetic neurodegenerative disorder. With a median age of onset of 40 years, patients will typically live 15–20 years following their diagnosis. In addition to this unfortunately bleak outlook, there are no current therapies to slow disease progression, and little is known regarding HD pathophysiological mechanisms. Graham et al. (2016) posit that a lack of HD [...]

Novel Huntington’s Disease Biomarkers

Huntington’s disease (HD) is a genetic neurodegenerative disorder. With a median age of onset of 40 years, patients will typically live 15–20 years following their diagnosis. In addition to this unfortunately bleak outlook, there are no current therapies to slow disease progression, and little is known regarding HD pathophysiological mechanisms. Graham et al. (2016) posit that a lack of HD [...]

Zika Virus Proteins Disrupt Neuronal Stem Cell Signaling Pathways

The outbreak of Zika virus (ZIKV) reported in Brazil earlier this year is associated with higher incidence of babies born with microcephaly. Liang et al. (2016) recently presented evidence of ZIKV protein disruption of neuronal signaling pathways, which inhibits development in fetal neuronal stem cells (fNSCs), showing both the molecular basis behind infection and indicating potential therapeutic targets.1 Although various research [...]

Zika Virus Proteins Disrupt Neuronal Stem Cell Signaling Pathways

The outbreak of Zika virus (ZIKV) reported in Brazil earlier this year is associated with higher incidence of babies born with microcephaly. Liang et al. (2016) recently presented evidence of ZIKV protein disruption of neuronal signaling pathways, which inhibits development in fetal neuronal stem cells (fNSCs), showing both the molecular basis behind infection and indicating potential therapeutic targets.1 Although various research [...]

High Reproducibility and Sensitivity Analysis of Bile Acids

Bile acids may be a useful tool for diagnosis of hepatobiliary diseases in infants. Further, bile acid concentration abnormalities can be associated with intrahepatic cholestasis, nondiabetic metabolic syndrome and type 2 diabetes mellitus. The human body synthesizes bile acids from cholesterol; synthesis occurs in the liver cells. This two-step process involves the formation of two primary bile acids, chalice acid (CA) and chenodeoxycholic acid (CDCA), which [...]

High Reproducibility and Sensitivity Analysis of Bile Acids

Bile acids may be a useful tool for diagnosis of hepatobiliary diseases in infants. Further, bile acid concentration abnormalities can be associated with intrahepatic cholestasis, nondiabetic metabolic syndrome and type 2 diabetes mellitus. The human body synthesizes bile acids from cholesterol; synthesis occurs in the liver cells. This two-step process involves the formation of two primary bile acids, chalice acid (CA) and chenodeoxycholic acid (CDCA), which [...]

Lung Cancer Biomarker Discovery through Metabolic Enzyme Activity

Sun et al. (2016) present a biomarker discovery study that searches for serum proteins as indicators of altered metabolic function in patients with lung cancer.1 Their method includes protein elution plate (PEP) technology, with mass spectrometric (MS) proteomic analysis for identification.  One of the pathophysiological mechanisms employed by cancer cells is a shift on cellular metabolism that favors their survival [...]

Lung Cancer Biomarker Discovery through Metabolic Enzyme Activity

Sun et al. (2016) present a biomarker discovery study that searches for serum proteins as indicators of altered metabolic function in patients with lung cancer.1 Their method includes protein elution plate (PEP) technology, with mass spectrometric (MS) proteomic analysis for identification.  One of the pathophysiological mechanisms employed by cancer cells is a shift on cellular metabolism that favors their survival [...]

Toxicant Biomarkers: Urinary Exposure Marker Discovery

Industrialization brings exposure to potentially dangerous chemicals through food products, personal care items and even contaminants in the air. Human biomonitoring allows researchers and clinicians to assess toxicant impact by interrogating body fluids for contaminants and their metabolites. However, while metabolite identification and quantification are crucial for understanding how chemical exposure impacts metabolism and disease pathogenesis, the detection process can [...]

Toxicant Biomarkers: Urinary Exposure Marker Discovery

Industrialization brings exposure to potentially dangerous chemicals through food products, personal care items and even contaminants in the air. Human biomonitoring allows researchers and clinicians to assess toxicant impact by interrogating body fluids for contaminants and their metabolites. However, while metabolite identification and quantification are crucial for understanding how chemical exposure impacts metabolism and disease pathogenesis, the detection process can [...]