Welcome to the world of translational and quantitative proteomics. This site was developed to provide researchers with useful information and tools for mass spectrometry (MS)-based approaches to protein quantification.

To understand the functions of individual proteins and their place in complex biological systems, it is often necessary to measure changes in protein abundance relative to changes in the state of the system. As such, modern proteomics has evolved from a qualitative technique into one that spans a continuum of qualitative and quantitative approaches.
MS has emerged as a powerful technology for system-wide identification and quantitation of proteins. It can be used for both unbiased discovery-based (untargeted) and targeted determination of changes in protein abundance.

New in translational and quantitative proteomics

Protein Expression Changes During Preeclampsia

Preeclampsia  is a dangerous complication in pregnancy and is potentially life-threatening for both mother and baby. Researchers such as Kim et al. are trying to reduce preeclampsia complications by establishing earlier diagnostics based on blood biomarkers.1 The team used a global proteomics strategy to look for PE candidate biomarkers in three pairs of plasma samples obtained from pregnant women in the early second [...]

Protein Expression Changes During Preeclampsia

Preeclampsia  is a dangerous complication in pregnancy and is potentially life-threatening for both mother and baby. Researchers such as Kim et al. are trying to reduce preeclampsia complications by establishing earlier diagnostics based on blood biomarkers.1 The team used a global proteomics strategy to look for PE candidate biomarkers in three pairs of plasma samples obtained from pregnant women in the early second [...]

Effects of Rosemary Extract on Colon Cancer Cells

  A team of researchers from Spain and Sweden recently examined the effects of rosemary (Rosmarinus officinalis L.) on colon cancer cell proliferation. It may seem like a feeble treatment for something as serious as cancer, but Valdés et al. explain that rosemary has documented health benefits, with its medicinal uses dating back thousands of years. The high antioxidant activity in rosemary comes [...]

Effects of Rosemary Extract on Colon Cancer Cells

  A team of researchers from Spain and Sweden recently examined the effects of rosemary (Rosmarinus officinalis L.) on colon cancer cell proliferation. It may seem like a feeble treatment for something as serious as cancer, but Valdés et al. explain that rosemary has documented health benefits, with its medicinal uses dating back thousands of years. The high antioxidant activity in rosemary comes [...]

Novel Huntington’s Disease Biomarkers

Huntington’s disease (HD) is a genetic neurodegenerative disorder. With a median age of onset of 40 years, patients will typically live 15–20 years following their diagnosis. In addition to this unfortunately bleak outlook, there are no current therapies to slow disease progression, and little is known regarding HD pathophysiological mechanisms. Graham et al. (2016) posit that a lack of HD biomarkers is impeding [...]

Novel Huntington’s Disease Biomarkers

Huntington’s disease (HD) is a genetic neurodegenerative disorder. With a median age of onset of 40 years, patients will typically live 15–20 years following their diagnosis. In addition to this unfortunately bleak outlook, there are no current therapies to slow disease progression, and little is known regarding HD pathophysiological mechanisms. Graham et al. (2016) posit that a lack of HD biomarkers is impeding [...]

Zika Virus Proteins Disrupt Neuronal Stem Cell Signaling Pathways

The outbreak of Zika virus (ZIKV) reported in Brazil earlier this year is associated with higher incidence of babies born with microcephaly. Liang et al. (2016) recently presented evidence of ZIKV protein disruption of neuronal signaling pathways, which inhibits development in fetal neuronal stem cells (fNSCs), showing both the molecular basis behind infection and indicating potential therapeutic targets.1 Although various research groups have shown [...]

Zika Virus Proteins Disrupt Neuronal Stem Cell Signaling Pathways

The outbreak of Zika virus (ZIKV) reported in Brazil earlier this year is associated with higher incidence of babies born with microcephaly. Liang et al. (2016) recently presented evidence of ZIKV protein disruption of neuronal signaling pathways, which inhibits development in fetal neuronal stem cells (fNSCs), showing both the molecular basis behind infection and indicating potential therapeutic targets.1 Although various research groups have shown [...]